Systems Biology and Network Analysis

Motivation

Recent technological advances have generated unprecedented volumes of single-cell, spatial, and multimodal omics data, creating new opportunities and challenges for understanding complex biological systems. While these data enable increasingly detailed molecular profiling, extracting mechanistic insight requires computational methods that can integrate information across biological scales and explicitly model network structure, dynamics, and causality.

This session focuses on cutting-edge computational approaches for systems-level and network-based analysis, including gene regulatory and signaling network inference, dynamic and causal modeling, and multi-omics data integration. By decoding the interplay of molecular components across cellular, tissue, and phenotypic contexts, this session aims to advance our understanding of disease mechanisms, toxicity, and other fundamental biological processes. The session bridges precision medicine and fundamental mechanism discovery, and creates synergies with PSB sessions in AI/ML and precision medicine by emphasizing interpretable, mechanism-oriented models.

Session Topics

We welcome submissions that advance our ability to analyze and interpret complex biological systems. Specific areas of interest include, but are not limited to:

• Gene regulatory, signaling, and metabolic network inference
• Dynamic, time-resolved, and causal network modeling
• Integration of single-cell and multimodal multi-omics data
• Spatial transcriptomics, spatial proteomics, and imaging data integrated with network biology
• Methods bridging molecular, cellular, tissue-level, and phenotypic scales
• Graph neural networks, foundation models, and biologically constrained machine learning for network inference
• Integration of large-scale perturbation data for causal and mechanistic discovery
• Network-based approaches for drug repurposing and combination therapy prediction
• Use of non-biological networks (e.g., semantic or conceptual networks) to study biological and behavioral phenomena

Session Organizers

Paper Submissions

Unlike the abstracts at most biology conferences, papers in the PSB proceedings are archival, rigorously peer-reviewed publications. PSB publications are Open Access and linked directly from MEDLINE/PubMed and Google Scholar for wide accessibility. They should be thought of as short journal articles that may be cited on CVs and grant reports.

Authors are invited to submit original research contributions for consideration. Submissions will undergo a rigorous peer-review process. PSB accepts submissions for full-length papers.

Papers should be formatted according to the guidelines provided on the official PSB 2027 website. Please see the PSB paper format template and submission instructions.

Travel Fellowships for Trainees

In previous years, PSB has often offered travel fellowships to support trainees (e.g., students, postdoctoral fellows) who wish to attend the conference. Information regarding the availability, eligibility criteria, and application process for travel fellowships for PSB 2027 will be announced on the conference website.

Poster Format

Poster presenters will be provided with an easel and a poster board 32"W x 40"H (80x100cm). One poster from each paid participant is permitted. See the submission portal web site for the instructions regarding poster submissions.